侯 虎

发布者:鞠磊发布时间:2015-03-06浏览次数:7906

侯虎,男,博士,教授,博士生导师。

邮箱:houhu@ouc.edu.cn houhuouc@163.com

联系电话:0532-82031936

一、个人简历

 中国海洋大学教授、博士生导师。2011年博士毕业于中国海洋大学,2011-2014年中国海洋大学食品科学与工程学院讲师,2011-2016年中国海洋大学药物化学博士后,2016-2017 Purdue University农业与生物工程系访问学者,2014-至今中国海洋大学食品科学与工程学院副教授、教授、博士生导师。

 主要研究方向为“海洋功能蛋白/肽的基础理论及应用开发”、“营养与功能食品、特医食品研究”、“海洋生物医学材料”等。围绕海洋生物蛋白,研究其组织结构特征、加工体系的变异性及热稳机制、目标蛋白/肽的获取、结构解析、构效评价等。近年来先后主持/参加国家自然科学基金、国家863计划、国家重点研发计划、省重点研发计划等国家级、省部级课题20余项,其中10余项为课题负责人。

 近年来发表学术文章100余篇,其中以第一/通讯作者发表SCI文章40余篇,申请专利32项,其中授权10余项,出版专著1部,曾获海洋科技进步一等奖、中国商业联合会科技进步一等奖、山东省高校科技进步一等奖、青岛科技进步一等奖、山东省科技进步二等奖、青岛市青年科技奖等奖项,担任国际著名期刊评审专家、国家自然科学基金等项目评审专家、青岛生物工程学会理事等。

二、教学情况

 承担本科生课程《食品工程原理》、《食品工程原理实验》与研究生课程《食品蛋白质理论与技术》等教学工作;主持教学改革项目4项,建立以学生为中心的线上与线下、虚拟与仿真、理论与实践相结合的立体式教学体系,出版专著1部,参编教材2部;指导本科生SRDP项目、国创项目10余项,指导学生参加全国大学生竞赛获特等奖、一等奖等多项奖励;指导研究生获国家奖学金、学术之星奖学金等。

三、科研项目情况

 近年来承担的科研项目如下:

1. 国家自然科学基金:鳕鱼皮肽对光老化皮肤基质胶原降解的拮抗机制及活性中心结构解析。(负责人)

2. 国家自然科学基金:高温高压即食海参体壁非酶自降解途径及其拮抗机制。(负责人)

3. 国家重点研发计划:新型水产食品功能基料与生物材料研发(子课题负责人)

4. 山东省海洋经济创新发展区域示范项目:海洋活性蛋白及其功能制品的开发与产业化。(子课题负责人)

5. 山东省重点研发计划项目:针对肿瘤人群的深海鱼低聚肽制备关键技术及肿瘤全营养配方食品开发。(负责人)

6. 国家重点研发计划:海洋生物资源的高值化利用技术与健康功能新产品的研发。(项目骨干)

7. 山东省自然科学基金:海参体壁热敏凝胶的自裂解特征及阻断机制研究。(负责人)

8. 教育部博士点基金:基于MAPK 通路的大马哈鱼皮活性肽抗皮肤光老化机制。(负责人)

9. 山东省重点研发计划项目:海洋功能肽的关键制备技术及创伤、感染、手术及其他应激状态全营养配方食品的研发。(子课题负责人)

10. 中国博士后特别资助项目:刺参胶原凝胶聚集态的分子交联与热特性的耦合性研究。(负责人)

11. 青岛海洋生物医药研究院项目:鱼皮源脱细胞真皮基质口腔修复膜制备及引导牙槽骨再生机理研究。(负责人)

12. 技术服务项目:Ⅱ型胶原蛋白特性与生物功能研究。(负责人)

13. 中国博士后面上项目:刺参胶原蛋白的聚集态表征及热稳性能研究。(负责人)

14. 中央高校科研专项项目:大马哈鱼皮BIO-ANNs靶向活性肽对光老化皮肤MMPs拮抗机制研究。(负责人)

15. 国家自然科学基金:具有骨密度增加作用的鱼卵唾液酸糖肽化学结构解析和作用机制研究。(项目骨干)

16. 国家自然科学基金:鳕鱼源螯合肽促矿物质吸收和转运机制及分子机理。(项目骨干)

17. 国家科技支撑计划:神经细胞功能调节食品成分的制备关键技术、活性评价及其应用。(项目骨干)

18. 国家863项目:高活性鱼骨钙肽螯合物制备关键技术研究与开发。(项目骨干)

四、代表性论著(第一或通讯作者):

 近年来发表的部分代表性学术论文(第一或通讯作者)如下:

1. Effect of calcium-binding peptide from pacific cod (Gadus macrocephalus) bone on calcium bioavailability in Rats. Food Chemistry, 2017, 221, 373-378.

2. A novel calcium-binding peptide from Antarctic krill protein hydrolysates and identification of binding sites of calcium peptide complex. Food Chemistry, 2018, 243, 389-395.

3. Novel hard capsule prepared by tilapia (Oreochromis niloticus) scale gelatin and konjac glucomannan: characterization, and in vitro dissolution. Carbohydrate Polymers, 2019, 206, 254-261.

4. Purification and identification of immunomodulating peptides from enzymatic hydrolysates of Alaska pollock frame. Food Chemistry, 2012, 134(2), 821-828.

5. Moisture absorption and retention properties, and activity in alleviating skin photodamage of collagen polypeptide from marine fish skin. Food Chemistry, 2012, 135(3), 1432-1439.

6. Interactions of quercetin, curcumin, epigallocatechin gallate and folic acid with gelatin. International Journal of Biological Macromolecules, 2018, 118, 124-131.

7. Physical properties and antioxidant activity of gelatin-sodium alginate edible films with tea polyphenols. International Journal of Biological Macromolecules, 2018, 118, 1377-1383.

8. Effects of oral administration of peptides with low molecular weight from Alaska Pollock (Theragra chalcogramma) on cutaneous wound healing. Journal of Functional Foods. 2018, 48, 682-691.

9. Functional calcium binding peptides from Pacific cod (Gadus macrocephalus) bone: calcium bioavailability enhancing activity and anti-osteoporosis effects in the ovariectomy- induced osteoporosis rat model. Nutrients, 2018, 10(9), 1325

10. Purification and characterization of a novel calcium-biding decapeptide from Pacific cod (Gadus Macrocephalus) bone: molecular properties and calcium chelating modes. Journal of Functional Foods, 2019, 52, 670-679

11. Physicochemical and Biocompatibility Properties of Type I Collagen from the Skin of Nile Tilapia (Oreochromis Niloticus) for Biomedical Applications. Marine Drugs, 2019, 17(3), 137

12. Effect of peptides from alaska pollock on intestinal mucosal immunity function and purification of active fragments.Nutrients, 2019, 11, 2517

13. Comprehensive assessment of Nile tilapia skin collagen sponges as hemostatic dressings. Materials Science & Engineering C, 2020, 109, 110532

14. Immunomodulatory activity of Alaska pollock hydrolysates obtained by glutamic acid biosensor - artificial neural network and the identification of its active central fragment. Journal of Functional Foods. 2016, 24, 37-47.

15. Protective effect of gelatin polypeptides from Pacific cod (Gadus macrocephalus) against UV Irradiation-Induced damages by inhibiting inflammation and improving transforming growth factor-β/Smad signaling pathway. Journal of Photochemistry and Photobiology B: Biology. 2016, 162, 633-640.

16. Protective effect of gelatin peptides from pacific cod skin against photoaging by inhibiting the expression of MMPs via MAPK signaling pathway. Journal of Photochemistry & Photobiology, B: Biology. 2016, 165, 34-41.

17. Effect of moisture status on the stability of thermal gels from the body wall of sea cucumbers (Apostichopus japonicus). LWT-Food Science and Technology, 2016, 74, 294-302.

18. Nile tilapia skin collagen sponge modified with chemical cross-linkers as a biomedical hemostatic material. Colloids and Surfaces B: Biointerfaces, 2017,159, 89-96.

19. Characterization of Pacific cod (Gadus macrocephalus) skin collagen and fabrication of collagen sponge as a good biocompatible biomedical material. Process Biochemistry, 2017, 63, 229-235.

20. Effects of cross-linking on mechanical, biological properties and biodegradation behavior of Nile tilapia skin collagen sponge as a biomedical material. Journal of the Mechanical Behavior of Biomedical Materials, 2018, 80, 51-58

21. Thermal degradation behavior of collagen from sea cucumber (Stichopus japonicus) using TG-FTIR analysis. Thermochimica Acta, 2018, 659, 166-171.

22. Identification of MMP-1 inhibitory peptides from cod skin gelatin hydrolysates and the inhibition mechanism by MAPK signaling pathway. Journal of Functional Foods, 2017, 33, 251-260.

23. Inhibition of melanogenic activity by gelatin and polypeptides from pacific cod skin in B16 melanoma cells. Journal of Food Biochemistry, 2011, 35, 1099-1116.

24. Optimization of enzymatic hydrolysis of Alaska pollock frame for preparing protein hydrolysates with low-bitterness. LWT-Food Science and Technology, 2011, 44, 421-428.

25. Preparation of immunomodulatory hydrolysates from Alaska pollock frame. Journal of the Science of Food and Agriculture, 2012, 92(15), 3029-3038.

26. Protective effect of cod (Gadus macrocephalus) skin collagen peptides on acetic acid-induced gastric ulcer in rats. Journal of Food Science. 2016, 81(7), H1807–H1815.

27. Characterization of acid- and pepsin-soluble collagen extracted from the skin of Nile tilapia (Oreochromis niloticus), International Journal of Biological Macromolecules, 2017, 99, 8-14.

28. Effects of early enteral nutrition supplemented with collagen peptides on post-burn inflammatory responses in a mouse model. Food & Function, 2017, 8, 1933-1941.